No problem. Simple answers.
1. If you go into Intelliremote PC Server and go to the Customize tab you will see Arrow Right, Arrow Down, etc in the list mapped to Mouse events. Simply change them to Key Event = "Arrow Down" etc and now you have remapped them to do the keyboard arrow keys. This is the power of Intelliremote.
2. As for those other events in the MCE Profile simply map them to whatever you want. for example a lot of users map the MCE Videos button to open Netflix in MCE.http://forum.melloware.com/viewtopic.php?f=1&t=8817